Yes. If you use multiple profiles in Chrome, Edge, Brave, or Opera (for example, a personal profile and a work profile), RJL System Cleaner detects and cleans all of them.
For Chrome and Edge, the app looks for profile directories named "Default", "Profile 1", "Profile 2", and so on in the browser's user data folder.
For Firefox, the app reads the profiles.ini configuration file to find all profile directories, including profiles with randomly generated folder names.
All profiles are cleaned together when you select a browser for cleaning. There is currently no option to clean individual profiles separately.